Bone Abstracts

In order to maintain bone remodeling balance, it is important to keep enough Ca absorption from the intestine. Vitamin D is required to increase Ca absorption from the gut. Because vitamin D acts via activation to 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney, native vitamin D cannot exert its full effect when the activation process is disturbed. Renal impairment is the main cause of deterioration of the activation of vitamin D. Aging is associated with the dev...

We previously reported that interleukin (IL)-11 plays an important role in the mechanical stress and PTH-induced stimulation of osteoblast differentiation and bone formation. Mechanical stress and PTH enhance IL-11 gene promoter activity and increase IL-11 expression. Increased IL-11 down-regulates dikkopf 1/2 (Dkk1/2) expression and stimulates canonical Wnt signaling, which enhances osteoblast differentiation. The present study was undertaken to clarify the physiological role...